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Quick Details

  • CAS No.: 139755-83-2
  • EINECS No.: /
  • Place of Origin: Henan, China (Mainland)
  • Type: API
  • Grade Standard: Medicine Grade
  • Brand Name: DeBao
  • Purity: 99.5%
  • Color: White powder
  • Molecular Weight: 474.5764
  • Density: 1.39g/cm3
  • Boiling point: 672.4°C at 760 mmHg
  • Flashing point: 360.5°C
  • Vapour pressure: 6.1E-18mmHg at 25°C
  • Melting point: 187~189℃
  • Grade standard: pharmaceutical grade
  • Packing: 1 kg / aluminum foil bag, 25 kgs / cardboard drum
  • Loss on drying: less than 0.5%

Packaging & Delivery

Packaging Details 10 g, 30 g, 100 g, 1 kg, 5 kg, 10 kg, 20 kg, /aluminum foil bag, outside by one small / larger carton
25 kg/ cardboard drum, inner by double sealed plastic bags
Delivery Time Within 2 to 3 working days

Product Description:

 

Many studies have proved. Nitric oxide (NO) is mainly caused by cavernous smooth muscle relaxation and the erection of the medium. Sildenafile for phosphodiesterase (PDE) V selective inhibitor, can enhance during sexual stimulation of no release induced penile erectile physiology reaction. No from nerve terminals and endothelial cells release combined with the corpus cavernosum smooth muscle receptors and activation of intracellular soluble guanylyl acid cycle enzyme, the latter in the participation of Mn2 +, prompting the guanosine triphosphate (GTP) variable for guanosine cyclic monophosphate (CGMP) and cGMP activated protein kinase G (PKG) and a small part of the protein kinase A (PKA) and activation of PKG and PKA activation Ca2 + pump, the intracellular Ca2 + level decreased by, resulting in corpus cavernosum smooth muscle relaxation, arterial inflow, phallic hyperaemia, stiff, erect. V cGMP can be present in the human cavernous body and vascular smooth muscle, which can make the PDE hydrolysis to GMP and block the NO-cGMP pathway of penile erection.. Sildenafile is PDE selective inhibitor of V, can prevent the degradation of cGMP, which can enhance the erectile response of excitement. In vitro experiments showed that the selectivity of this raw material on PDE V, more than PDE of other isozymes. It relates to the contraction of the heart of PDE III had no effect, but at higher doses can inhibit PDE VI of the retina and visual impact.

 

Name:

Sildenafil

Another Name:

5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

CAS No.:

139755-83-2

Molecular Formula:

Molecular Weight:

474.5764

InChI:

InChI=1/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

Density:

1.39g/cm3

Boiling Point:

672.4°C at 760 mmHg

Flash Point:

360.5°C

Vapour Pressure:

6.1E-18mmHg at 25°C

 

     Product name

 

   Dosage                            Function                                     

 

1. Sildenafile citrate

 

100-200mg      

                 To make tablets or capsules

 

2. Sildenafile mesylate

 

100-150mg          To make pills or capsules , or health-care wine

 

3. Sildenafile base

 

100-120mg                   To make pills /capsules

 

4. Wine soluble Sildenafile

base

100-120mg                  To male health-care wine exclusively

 

Packaging and Shipping:

Packing Detail: 1 kg ( net weight) / sealed aluminum foil bag, outside by one carton, 25 kgs ( net weight) / cardboard drum.

 

Shipping Information:  For small quantity order, by Air:  DHL, FEDEX, TNT, UPS, EMS etc.,

                                         For large quantity requirement, by Sea

                                         MOQ is 10g an an initial smaple order to test the effectiveness of the raw materials.

 

 

 

We have been supplying the ED pharmaceutical raw materials for man, kindly check the following of this kind of item names please. Very well thanks

 

-Sildenafil citrate, Dosage : 200mg

-Sildenafil mesylae, 150mg

-Sildenafil base, 120mg

-Wine soluble sildenafil base, 120mg

-Tadalafil ( 99.0% purity and 99.8% assay), 20mg

-Vardenafil, 20mg

-Mirodenafil, 30mg

-Acetildenafil / Hongdenafil, 15mg

-Dapoxetine, 20mg

-Dapoxetil HCL, 20mg

-Jinyang alkali /Jinyang base, 80mg

-Wine soluble Jinyang alkali, 50-80mg

-Xin jinyang alkali, 120mg

-Xinyang alkali, 150mg

-Crepis base 150mg 

 

 

Should any interest, kindly keep us posted.Thanks

Zhengzhou Debao Fine Chemical Co.,Ltd

Phone: 0086 18236961608

Contact person: Jessica Guo

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